Perphenazine

Properties

Related Categories	Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Glutamine Metabolism and Oncogenesis, Inhibitors and Activators of Glutamine Metabolic Pathways, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, P, Proteins and Derivatives, Schering Plough More...
storage temp.	2-8°C
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

Description

Biochem/physiol Actions

D₂ dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P6402.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Related Papers

BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats. Okumura, K., et al. J. Neural Transm. Gen. Sect. 103, 1153-1161, (1996)

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Symbol	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280
Hazard Codes (Europe)	Xn
Risk Statements (Europe)	22-43
Safety Statements (Europe)	28-36/37/39-45
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Cancer, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Transcription