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P6532 Sigma

Prostaglandin E2

γ-irradiated, powder, BioXtra, suitable for cell culture

Synonym: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE2

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Properties

Related Categories Biochemicals and Reagents, Cell Culture, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids,
InChI Key   XEYBRNLFEZDVAW-ARSRFYASSA-N
sterility   γ-irradiated
product line   BioXtra
form   powder
potency   0.25-100 ng/mL
solubility   ethanol: soluble1 mg/mL
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

Description

Application

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.

Physical form

powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions

Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UK8000000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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