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P6624 Sigma

PS-1145 dihydrochloride

≥98% (HPLC), solid

Synonym: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I Kappa B Kinase (IKK),
InChI Key   QTDCBADLGJZBHP-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   yellow
solubility   DMSO: >3 mg/mL at ~60 °C, clear (with warming for 2 minutes)
  methanol: water (1:1): ≥5 mg/mL at 60 °C (With warming for 5 minutes.)
storage temp.   2-8°C

Description

Biochem/physiol Actions

PS-1145 is an IKB kinase (IKK) inhibitor.

Features and Benefits

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

MAPKKKs

Mitogen-activated protein kinase (MAPK) signaling pathways mediate cellular responses to many stimuli including growth factors, hormones, cytokines and environmental stresses. MAPK pathways can be di...
Keywords: Apoptosis, Cancer, Degradations, Environmental, Growth factors, Hormones, Inflammation, Phosphorylations, RNA immunoprecipitation, Ubiquitinations

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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