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P7097 Sigma

Monoclonal Anti-Interleukin-4−R-Phycoerythrin antibody produced in mouse

clone 3007.11, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-IL-4, Monoclonal Anti-Interleukin-4

Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Intracellular Cytokine Staining, Antibodies to Interleukins and Receptors,
species reactivity   human
application(s)   flow cytometry: suitable
clone   3007.11, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... IL4(3565)
biological source   mouse
conjugate   phycoerythrin (R-PE) conjugate

Description

Immunogen

recombinant human IL-4

Physical form

25 μg of antibody in 1.0 mL of saline containing up to 0.5% bovine serum albumin. Contains 0.1% sodium azide as a preservative.

Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.

Preparation Note

Purified antibody is conjugated to R-phycoerythrin (PE).

Biochem/physiol Actions

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Conjugation of R-Phycoerythrin to the antibody enables its use in immunofluorescent techniques.

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