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P7136 Sigma

Pyrazinecarboxamide

Synonym: Pyrazinamide, Pyrazinoic acid amide

Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antimycobacterial,
mp   189-191 °C(lit.)
solubility   H2O: soluble50 mg/mL

Description

Packaging

10, 25, 100 g in poly bottle

Application

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention 1 and mechanisms of resistance 2.

Biochem/physiol Actions

The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide 3. Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

Price and Availability

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