Poly-D -lysine hydrobromide
average mol wt 30,000-70,000, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture
DOWNLOAD MSDS (PDF)Synonym: PDL
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CAS Number 27964-99-4
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Linear Formula
D -Lys-(D -Lys)n-D -Lys · xHBr -
MDL number MFCD00131934
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PubChem Substance ID 24898835
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Popular Documents: Product Information Sheet (PDF) | RAMAN FTIR (PDF)
Properties
| Related Categories | Amino Acids, Attachment Factors, Attachments Factors, Biochemicals and Reagents, Cell Culture, |
| sterility | γ-irradiated |
| product line | BioReagent |
| form | lyophilized powder |
| mol wt | average mol wt 30,000-70,000 |
| suitability | suitable for cell culture |
| storage temp. | −20°C |
Description
Analysis Note
Molecular weight based on viscosity.
Application
Poly-lysine with mol. wt. >30,000 is useful in promoting cell adhesion to solid substrates.
Recommended as a cell culture substratum when using 0.5 - 1.0 mL of a 0.1 mg/ml solution to coat 25 cm2. Optimal conditions for attachment must be determined for each cell line and application.
Other Notes
This product has a lowerer binding site density, but is less viscous than P6407. It is a poly-D-lysine that can be used with cells that digest poly-L-lysine polymers.
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
General description
Poly-lysine polymers are useful molecules to prepare surfaces for cell attachment. Poly-lysine polymers are available in L and D conformations. Poly-L-lysine polymers can be digested by some cell types, whereas poly-D-lysines are stable. Poly-lysine polymers from 70 to 300 kDa provide sufficient attachment site density for good cell adherence. However, higher the molecular weight poly-lysine polymers are more viscous and difficult to work with.
The choice of poly-lysine polymer for a specific cell type and application should account for the susceptibility of the polymer to digestion, the required attachment site density and the difficulty in handling.
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