Synonym: (±)-threo-PDMP hydrochloride, PDMP hydrochloride
|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K,|
Glucosylceramide synthase inhibitor; blocks formation of glucosylceramide from ceramide.
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≥98% (HPLC), powder
film (dried in situ)
Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells. Inokuchi, et al. J. Cell Physiol. 141, 573-583, (1989)
Radin, et al. J. Lipid Res. 26, 183-213, (1993)
Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells. Weber, et al. Br. J. Pharmacol. 123, 906-910, (1998)
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