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  • P7609 - Anti-Serine/Threonine Protein Phosphatase 1γ1 antibody produced in rabbit

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P7609 Sigma

Anti-Serine/Threonine Protein Phosphatase 1γ1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Primary Antibodies,
species reactivity   human, bovine, mouse, rat
application(s)   immunoprecipitation: suitable
  microarray: suitable
  western blot: 1:500-1:1,000 using total rat brain homogenate
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~36 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PPP1CC(5501)
mouse ... Ppp1cc(19047)
rat ... Ppp1cc(24669)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide (TPPRGMITKQAKK) corresponding to the C-terminus of the protein phosphatase 1γ1 catalytic subunit (amino acid residues 311-323).

General description

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. Protein phosphatases, like kinases, are a class of enzymes that regulate protein phosphorylation. The serine/threonine phosphatases have been classified into four groups which include PP1, PP2A, PP2B (also termed calcineurin) and PP2C on the basis of differences in their biochemical properties. PP1 isoforms catalyze a wide range of protein dephosphorylation reactions in a tightly regulated manner and is expressed abundantly in the brain. PP1 has broad functions covering glycogen metabolism, protein synthesis, cell cycle and growth and muscle contractility. PP1 forms exclusive complexes with >50 regulatory subunits that allows for restricted subcellular location and thereby distinct cellular functions. There are 3 isoforms of PP1 (α, β and γ1) with 90% homology. PP1γ1 is expressed in brain and has been reported to be crucial for cell proliferation in lung carcinoma cells, A549. .
The antibody specifically recognizes protein phosphatase 1γ1 isoform.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.

Application

Anti-Serine/Threonine Protein Phosphatase 1γ1 antibody may be used for detection by immunoblotting in total rat brain homogenate at a working dilution of 1:500-1:1000. It is suitable for immunoprecipitation and protein microarray applications.

Price and Availability


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