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P7626 Sigma

Phenylmethanesulfonyl fluoride

≥98.5% (GC)

Synonym: α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase. Not as effective or as toxic as DFP. Effective concentration 0.1-1 mM. Half-life = 1 hr. at pH 7.5.

Packaging

1, 5, 25, 100 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.

Price and Availability


Refer a colleague - New Lab Start-Up program
Safety & Documentation
Protocols & Articles

Articles

Recombinant Protein Expression in Saccharomyces cerevisiae

Expressing recombinant proteins in yeast has many advantages, simple protocols, use of basic reagents, appropriate processing of eukaryotic proteins, and scalability. Sigma® Life Science is an essent...
Keywords: Cell disruption, Gene expression, transformation

Roar Assay Kits for Studies in Lipoprotein Metabolism

This technical article is a compilation of select fluorescence-based activity assays developed by Roar Biomedical now offered through Sigma-Aldrich in kit format. The methods are well-characterized, ...
Robert Brocia
Roar Biomedical, Inc.
Keywords: Addition reactions, Cardiovascular, Chromatography, Clinical, Detection methods, Drug discovery, Esterifications, Gas chromatography, High performance liquid chromatography, Separation, Thin layer chromatography

Protocols

MTP Activity Assay Kit Protocol

The kit is sufficient for 100 assays in 200 µL total assay volume. Donor Particle                                0.4 mL     Catalog Number MAK110A Acceptor Particle                            0.4 mL ...
Keywords: Buffers, Homogenization, Sample preparations

Peer-Reviewed Papers
15

References

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A8456 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, ≥97%

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