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P7626 Sigma

Phenylmethanesulfonyl fluoride

≥98.5% (GC)

Synonym: α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride

Description

Frequently Asked Questions

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Application

Inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase. Not as effective or as toxic as DFP. Effective concentration 0.1-1 mM. Half-life = 1 hr. at pH 7.5.

Packaging

1, 5, 25, 100 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions

Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.1

Price and Availability


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