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P7674 Sigma

Pyrantel (+)-tartrate salt

Synonym: 1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents,
InChI Key   VWRCYAZJKNPEQR-NIEARKAZSA-N
assay   ≥99% (TLC)
composition   Carbon, 49.2-51.8%
  Nitrogen, 7.5-8.3%
solubility   H2O: soluble4.0 mL, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )
Mode of action   enzyme | inhibits

Description

Application

Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).

Biochem/physiol Actions

Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. Cholinesterase inhibitor.

Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. This is a cholinesterase inhibitor. It causes spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
UW0249000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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