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P7965 Sigma

Monoclonal Anti-P-Glycoprotein (MDR) antibody produced in mouse

clone F4, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Multi-Drug Resistance, Antibodies to Drug Efflux Pumps,
species reactivity   hamster, human
application(s)   immunocytochemistry: suitable
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human kidney sections
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  radioimmunoassay: suitable using cell-surface RIA
  western blot: suitable
clone   F4, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt 170-180 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ABCB1(5243)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

Specificity

The antibody recognizes an epitope located in the amino terminal half of P-glycoprotein (Pgp), at the third extracellular loop of the molecule. The epitope is resistant to formalin fixation and periodate oxidation. The antibody detects specifically human MDR1 P-glycoprotein, but does not appear to recognize the human MDR3 product, nor the mouse mdr1a, mdr1b or the mdr3 P-glycoprotein.

Price and Availability


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