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  • P8087 - Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse

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P8087 Sigma

Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse

clone 15F11, ascites fluid, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
species reactivity   human, bovine, canine
application(s)   immunocytochemistry: suitable using cultured cells
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  indirect immunofluorescence: 1:1,000 using cultured MDBK cells
  microarray: suitable
  western blot: 1:2,000 using cultured MDBK cells
clone   15F11, monoclonal
antibody form   ascites fluid
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 85 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... JUP(3728)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant chicken plakoglobin.

General description

Plakoglobin is a desmosomal protein that regulates developmental signalling in vertebrates. Tyrosine phosphorylation of plakoglobin has been linked to adenocarcinomas . Plakoglobin may function as a tumor suppressor in ovarian and breast cancers . Monoclonal anti-plakoglobin (catenin γ) antibody specifically binds to plakoglobin (85kDa band and a possibly lower band) by immunoblotting. The antibody reacts with plakoglobin in bovines, humans and dogs, but does not react with β catenin.

Application

Monoclonal anti-plakoglobin (catenin γ) antibody is suitable for use in immunocytochemistry (using MDCK cells), immunoprecipitation, and in immunoblotting . The antibody may also be used for immunohistochemistry (frozen sections), microarray, western blot (1:500, using cultured MDBK cells) and indirect immunofluorescence (1:1000, using cultured MDBK cells).

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