|Related Categories||Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GABA and Glycine Receptor Modulators,|
GABAA receptor antagonist; binds to the GABA receptor-linked Cl− channel.
Active component of picrotoxin
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P264-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||28|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 2811 6.1 / PGII|
Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Li P, Khatri A, Bracamontes J, et al. Mol. Pharmacol. 77(4), 539-46, (2010)
Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. Carland JE, Johnston GA, and Chebib M Eur. J. Pharmacol. 580(1-2), 27-35, (2008)
Investigation of structural requirements for inhibitory activity at the rat and housefly picrotoxinin binding sites in ionotropic GABA receptors using DISCOtech and CoMFA. Ju XL, Hao YL, Pei JF, et al. Chemosphere 69(6), 864-71, (2007)
Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes. Eguchi Y, Ihara M, Ochi E, et al. Insect Mol. Biol. 15(6), 773-83, (2006)
Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: transmitter uptake gets faster during development. Diamond JS J. Neurosci. 25(11), 2906-16, (2005)
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. Huang SH, Duke RK, Chebib M, et al. Eur. J. Pharmacol. 464(1), 1-8, (2003)
Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. Martín-Ruiz R, Puig MV, Celada P, et al. J. Neurosci. 21(24), 9856-66, (2001)
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms. Baufreton J, Garret M, Dovero S, et al. J. Neurophysiol. 86(1), 75-85, (2001)
Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists. Hirata K, Ishida C, Eguchi Y, et al. Insect Mol. Biol. 17(4), 341-50, (2008)
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