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P8688 Sigma

(S)-(−)-Propranolol hydrochloride

≥98% (TLC), powder

Synonym: (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca,
InChI Key   ZMRUPTIKESYGQW-UQKRIMTDSA-N
assay   ≥98% (TLC)
form   powder
optical activity   [α]25/D −25.5°, c = 1.0 in ethanol(lit.)
mp   193-195 °C(lit.)
solubility   ethanol: soluble10 mg/mL
  DMSO: <14.5 mg/mL
  H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
originator   AstraZeneca
storage temp.   2-8°C
Gene Information   human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)

Description

Packaging

100, 500 mg in glass bottle

Biochem/physiol Actions

Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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