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P8765 Sigma

Ammonium pyrrolidinedithiocarbamate

~99%

Synonym: 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC

  • CAS Number 5108-96-3

  • Linear Formula C5H9NS2 · NH3

  • Molecular Weight 164.29

  •  Beilstein Registry Number 3730472

  •  MDL number MFCD00012720

  •  PubChem Substance ID 24278658

  • Popular Documents:  FTIR (PDF)  

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Packaging

1, 5, 25, 100 g in glass bottle

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. http://www.sigmaaldrich.com/etc/medialib/docs/Sigma-Aldrich/General_Information/shippingandlong-termstoragev3.Par.0001.File.tmp/shippingandlong-termstoragev3.pdf
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
How can I prepare a solution of Product P8765, Ammonium pyrrolidinedithiocarbamate?
Ammonium pyrrolidinedithiocarbamate is soluble in water at a concentration of approximately 50 mg/mL.
What is the solution stability of Product P8765, Ammonium pyrrolidinedithiocarbamate?
Sigma-Aldrich has not performed a controlled solution stability test on PDTC. However, we have found that aqueous stock solutions are typically stable for at least one month when stored at -20 °C.
What are the difference among the Ammonium pyrrolidinedithiocarbamate Products P8765, 09935, 71935?
Both products P8765 (Sigma brand) and 09935 (Fluka brand) are the same chemical compound but have different specifications. The specification for P8765 is found in the link: http://www.sigmaaldrich.com/catalog/DataSheetPage.do?brandKey=SIGMA&symbol=P8765. For product 09935, the specifications at our website are in the link below: http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=09935|FLUKA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC. Product 71935 is the sodium salt, not the ammonium salt of pyrrolidinedithiocarbamate.
What are some functions reported for Product P8765, Ammonium pyrrolidinedithiocarbamate?
PDTC has been reported to repress vascular cell adhesion molecule-1 (VCAM-1) activation by Interleukin-1β in cultured human umbilical vein endothelial calls. Marui, M., et al., J. Clin. Invest, 92, 1866 (1993).  It inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Sherman, M.P., et al., Biochem. Biophys. Res. Commun. 191, 1301-1308 (1993).  It is an Inhibitor of nuclear factor kappa B., Eberhardt, et al. Biochem. Biophys. Res. Commun. 200, 163 (1994). PDTC at 100  µM, totally inhibited the NF-kappa B response in intact cells. Schreck, R., et al., J. Exp. Med. 175 , 1181-1194 (1992). It activates cAMP-dependent protein kinase (PKA) in a colorectal cancer cell line. Chinery, R., et al., J. Biol. Chem., 272, 30356 - 30361, (1997).
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Protocols & Articles
Peer-Reviewed Papers
15

References

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