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P8765 Sigma

Ammonium pyrrolidinedithiocarbamate

~99%

Synonym: 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC

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Description

Frequently Asked Questions

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Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Packaging

1, 5, 25, 100 g in glass bottle

Price and Availability

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Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



TruPAGE™ Pre-cast Polyacrylamide Gels


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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3

Protocols & Articles

Peer-Reviewed Papers

References

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Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Sherman, M. P., et al. Biochem. Biophys. Res. Commun. 191, 1301-1308, (1993)

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Differential Regulation Of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) And IRAK-2 By MicroRNA-146a And NF-{kappa}B In Stressed Human Astroglial Cells And In Alzheimer Disease. Cui, J.G., et al. J. Thorac. Cardiovasc. Surg. 285, 38951-60, (2010)

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Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases. Sylvester J, El Mabrouk M, Ahmad R, et al. Cell Physiol. Biochem. 30(3), 563-74, (2012)

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[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells]. Hu Z, Huang J, Li Z, et al. Zhongguo Fei Ai Za Zhi 15(5), 277-80, (2012)

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Pyrrolidine dithiocarbamate augments Hg(2+)-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways. Huang CF, Liu SH, and Lin-Shiau SY Toxicol. Lett. 214(1), 33-45, (2012)

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A near-infrared-emitting CdTe/CdS core/shell quantum dots-based OFF-ON fluorescence sensor for highly selective and sensitive detection of Cd2+. Gui R, An X, Su H, et al. Talanta 94, 257-62, (2012)

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NF-κB contributes to the detrimental effects of social isolation after experimental stroke. Venna VR, Weston G, Benashski SE, et al. Acta Neuropathol. 124(3), 425-38, (2012)

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Ammonium pyrrolidine dithiocarbamate anchored Symphoricarpus albus biomass for lead(II) removal: batch and column biosorption study. Akar ST, Arslan D, and Alp T J. Hazard. Mater. 227-228, 107-17, (2012)

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Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation. Kang CH, Jayasooriya RG, Dilshara MG, et al. Food Chem. Toxicol. 50(12), 4270-6, (2012)

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Arsenic speciation in water and snow samples by adsorption onto PHEMA in a micro-pipette-tip and GFAAS detection applying large-volume injection. Döker S, Uzun L, and Denizli A Talanta 103, 123-9, (2013)

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Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells. Kittaka M, Shiba H, Kajiya M, et al. J. Periodont. Res. 48(2), 228-34, (2013)

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RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway. Li Q, Li M, Wang YL, et al. Cell Physiol. Biochem. 29(3-4), 361-72, (2012)

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Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. Yasuhiro Horita et al Bioorg. Med. Chem. Lett. 21, 899-903, (2011)

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Tumor necrosis factor-α and interleukin-1β expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7. Kim JS, Kim KD, Na HS, et al. Mol. Oral Microbiol. 27(3), 149-59, (2012)

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Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade. Feng H, Kang C, Dickman JR, et al. Exp. Physiol. 98(3), 784-95, (2013)

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Pyrrolidine dithiocarbamate inhibits herpes simplex virus 1 and 2 replication, and its activity may be mediated through dysregulation of the ubiquitin-proteasome system. Qiu M, Chen Y, Cheng L, et al. J. Virol. 87(15), 8675-86, (2013)

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Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats. Zhao Z, Huang G, Wang B, et al. Behav. Brain Res. 238, 44-7, (2013)

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Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact. Reid PE, Brown NJ, and Holen I Mol. Cancer 8, 49, (2009)

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The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Sun YL, Zhang XY, Sun T, et al. Peptides 47, 124-32, (2013)

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Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats. Li ZQ, Rong XY, Liu YJ, et al. Biochem. Biophys. Res. Commun. 438(4), 628-34, (2013)

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Determination of arsenic in chicken feed by hydride generation atomic absorption spectrometry after pre-concentration with polyurethane foam. Dos Passos AS, Néri TS, Maciel MV, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(11), 1689-95, (2012)

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Lipopolysaccharide regulates MMP-9 expression through TLR4/NF-κB signaling in human arterial smooth muscle cells. Li H, Xu H, and Sun B Mol. Med. Report. 6(4), 774-8, (2012)

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Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia-ischemia in neonatal rats. Wang Z, Zhao H, Peng S, et al. Exp. Neurol. 249, 74-82, (2013)

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Pyrrolidine dithiocarbamate as an effector and trigger in ischemia-reperfusion injury in adipocutaneous flaps in rats. Dacho A, Hanusch C, Lyutenski S, et al. J. Otolaryngol. Head Neck Surg. 41(3), 176-82, (2012)

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S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-κB-dependent MMP-9 signal. Zhang J, Zhang DL, Jiao XL, et al. Eur. Rev. Med. Pharmacol. Sci. 17(17), 2372-82, (2013)

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PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Wang W, Lin Q, Lin R, et al. Exp. Cell Res. 319(10), 1523-33, (2013)

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Pyrrolidine dithiocarbamate improves mortality in a rat model of severe hemorrhage. Montegudo AE, Palilonis MA, Moore CC, et al. J. Surg. Res. 179(1), e149-55, (2013)

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Norepinephrine activates NF-κB transcription factor in cultured rat pineal gland. Villela D, de Sá Lima L, Peres R, et al. Life Sci. 94(2), 122-9, (2014)

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Fractalkine stimulates cell growth and increases its expression via NF-κB pathway in RA-FLS. Guo X, Pan Y, Xiao C, et al. Int. J. Rheum. Dis. 15(3), 322-9, (2012)

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Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. Roy A, Modi KK, Khasnavis S, et al. PLoS ONE 9(7), e101883, (2014)

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Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats. Kimura K, Ohkita M, Koyama M, et al. Life Sci. 91(13-14), 644-50, (2012)

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2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro. Wang Q, Zhao Y, Sun M, et al. Toxicol. In Vitro 28(7), 1183-9, (2014)

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Mucin 5 subtype AC expression and upregulation in the nasal mucosa of allergic rhinitis rats. Wang W and Zheng M Otolaryngol. Head Neck Surg. 147(6), 1012-9, (2012)

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Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils. Alba G, Santa-María C, Reyes-Quiroz ME, et al. J. Endocrinol. 214(3), 399-408, (2012)

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Lidocaine attenuates lipopolysaccharide-induced inflammatory responses in microglia. Yuan T, Li Z, Li X, et al. J. Surg. Res. 192(1), 150-62, (2014)

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NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis. Raspé C, Höcherl K, Rath S, et al. Cytokine 61(1), 97-103, (2013)

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SDF-1 promotes ox-LDL induced vascular smooth muscle cell proliferation. Li LX, Zhang XF, Bai X, et al. Cell Biol. Int. 37(9), 988-94, (2013)

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p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells. Dong X, Li JC, Jiang YY, et al. J. Asian Nat. Prod. Res. 14(11), 1008-19, (2012)

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Myocardial infarction induces sympathetic hyperinnervation via a nuclear factor-κB-dependent pathway in rabbit hearts. Wang Y, Suo F, Liu J, et al. Neurosci. Lett. 535, 128-33, (2013)

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Beil. 20,V,1,331

Corp MSDS 1 (2), 3014:A / FT-IR 2 (1), 1413:B / FT-IR 1 (1), 834:C / IR-Spectra (2), 439:D / IR-Spectra (3), 495:G / NMR-Reference 2 (1), 691:A / RegBook 1 (1), 979:C / Sigma FT-IR 1 (2), 875:B / Structure Index 1, 152:D:8

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