Progesterone

Papers

Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents. Kadegowda, A.K., et al. J. Dairy Sci. 92, 4276-89, (2009)

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In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow. Hu, H., et al. PLoS ONE 4, 7636, (2009)

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Preparation of rat brain aggregate cultures for neuron and glia development studies. Koito, H., and Li, J. J. Vis. Exp. , (2009)

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Internalization of Coxsackievirus A9 Is Mediated by {beta}2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin Heikkila, O., et al. J. Virol. 84, 3666-81, (2010)

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High content screening of cortical neurons identifies novel regulators of axon growth. Blackmore, M.G., et al. Mol. Cell. Neurosci. 44, 43-54, (2010)

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Methylation At Global LINE-1 Repeats In Human Blood Are Affected By Gender But Not By Age Or Natural Hormone Cycles. El-Maarri, O., et al. PLoS ONE 6, e16252, (2011)

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Long-Term Monitoring Of Fecal Steroid Hormones In Female Snow Leopards (Panthera Uncia) During Pregnancy Or Pseudopregnancy. Kinoshita, K., et al. PLoS ONE 6, e19314, (2011)

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Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats. Zhiping Yu et al Physiol. Behav. 95, 501-7, (2009)

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Hormonal modulation of phonotaxis and advertisement-call preferences in the gray treefrog (Hyla versicolor). Noah M. Gordon et al Horm. Behav. 55, 121-7, (2009)

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Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male rats. Di Wu et al Horm. Behav. 56, 299-308, (2009)

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A balanced diet is necessary for proper entrainment signals of the mouse liver clock. Akiko Hirao et al PLoS ONE 4, e6909, (2009)

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Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. Alexandre Gonçalves et al PLoS ONE 6, e19370, (2011)

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Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice. Nanhai G Chen et al J. Transl. Med. 9, 164, (2011)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. Liqin Zhao et al J. Med. Chem. 48, 3463-6, (2005)

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Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Christian Laggner et al J. Med. Chem. 48, 4754-64, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Docking and three-dimensional quantitative structure-activity relationship (3D QSAR) analyses of nonsteroidal progesterone receptor ligands. Annu A Söderholm et al J. Med. Chem. 49, 4261-8, (2006)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist. Puwen Zhang et al Bioorg. Med. Chem. 15, 6556-64, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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New functional assay of P-glycoprotein activity using Hoechst 33342. Henrik Müller et al Bioorg. Med. Chem. 15, 7470-9, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)

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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. Artem Cherkasov et al J. Med. Chem. 51, 2047-56, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline. Bijan Pedram et al J. Med. Chem. 51, 3696-9, (2008)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. Jeffrey C Kern et al Bioorg. Med. Chem. Lett. 18, 5015-7, (2008)

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Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Wang-Fun Fong et al Bioorg. Med. Chem. 16, 3694-703, (2008)

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Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Anne Pick et al Bioorg. Med. Chem. 16, 8224-36, (2008)

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Integrating high-content screening and ligand-target prediction to identify mechanism of action. Daniel W Young et al Nat. Chem. Biol. 4, 59-68, (2008)

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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. José Marco-Contelles et al J. Med. Chem. 52, 2724-32, (2009)

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Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Pelayo Camps et al J. Med. Chem. 52, 5365-79, (2009)

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Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. Christopher J MacNevin et al J. Med. Chem. 52, 6012-23, (2009)

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4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Thomas S Dexheimer et al J. Med. Chem. 52, 7122-31, (2009)

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Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Mariana P Arce et al J. Med. Chem. 52, 7249-57, (2009)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. Scott K Thompson et al Bioorg. Med. Chem. Lett. 19, 4777-80, (2009)

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Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+. Palwinder Singh et al Bioorg. Med. Chem. 17, 2423-7, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. Deborah M Roll et al J. Nat. Prod. 72, 1944-8, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Waël Zeinyeh et al Bioorg. Med. Chem. Lett. 20, 3165-8, (2010)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation. P. Singh, et al., Bioorg. Med. Chem. 18, 4212-4223, (2010)

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Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. Yongli Du et al Bioorg. Med. Chem. 18, 4255-68, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter. Waël Zeinyeh et al Eur. J. Med. Chem. 45, 2480-8, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high ?? receptor affinity. Torsten Schläger et al J. Med. Chem. 54, 6704-13, (2011)

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Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 1744-7, (2011)

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Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Naoya Nagata et al Bioorg. Med. Chem. Lett. 21, 6310-3, (2011)

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Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone. Lautaro D Alvarez et al Bioorg. Med. Chem. 19, 1683-91, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Gema C González-Muñoz et al Eur. J. Med. Chem. 46, 2224-35, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association. Qiu, M., and Lange, C.A. J. Steroid Biochem. Mol. Biol. 85, 147-157, (2003)

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Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Lanari, C., and Molinolo, A.A. Breast Cancer Res. 4, 240-243, (2002)

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The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Anderson, E. Breast Cancer Res. 4, 197-201, (2002)

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Steroid hormone regulation of angiogenesis in the primate endometrium. Albrecht, E.D., and Pepe, G.J. Front. Biosci. 8, 416-429, (2003)

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Progesterone and the control of uterine cell proliferation and differentiation. Rider, V. Front. Biosci. 7, 1545-1555, (2002)

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Merck 14,7773

Beil. 7,IV,2395

Aldrich MSDS 1, 1539:B / Corp MSDS 1 (2), 2944:C / FT-IR 1 (2), 1052:B / FT-IR 2 (3), 4228:C / FT-NMR 1 (3), 578:A / IR-Spectra (3), 1496:F / RegBook 1 (2), 2859:O / Sax 6, 2290 / Sigma FT-IR 1 (1), 1316:A / Structure Index 1, 458:D:3