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P8859 Sigma

Anti-Protein Phosphatase X/C Interior antibody produced in sheep

IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, PR-PR,
species reactivity   bovine, mouse, human, rat
application(s)   immunocytochemistry: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~34 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PPP4C(5531)
mouse ... Ppp2ca(56420)
rat ... Ppp4c(171366)
biological source   sheep
conjugate   unconjugated

Description

Immunogen

highly purified peptide corresponding to amino acid residues 289-302 of protein phosphatase X/C.

General description

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. Protein phosphatases, like kinases, are a class of enzymes that regulate protein phosphorylation. The serine/threonine phosphatases have been classified into four groups which include PP1, PP2A, PP2B (also termed calcineurin) and PP2C on the basis of differences in their biochemical properties. Protein Phosphatase X/C (or PP4) is a member of PP2A subfamily and shares 65% structural idENTITY_TYPE_CODE with PP2A in humans. PPX/C is actively involved in regulation of growth and organization of microtubule at the centrososmes and centrosome maturation during cell division by mitosis and meiosis. PPX/C reportedly has a pro-apoptotic role in T lymphocytes. PPX/C takes part in important cellular processes through signaling pathways involving NF-κB and c-Jun N-terminal kinase
Anti-Protein Phosphatase X/C Interior recognizes an internal sequence of protein phosphatase XCatalytic domain (34 kDa).

Physical form

Solution supplied at 1 mg/mL in phosphate buffered saline with 0.08% sodium azide.

Application

Anti-Protein Phosphatase X/C is suitable for immunoblotting at a working dilution of 1:500-1:1000. The recommended dilution for immunocytochemistry is 1:500-1:1000.

Price and Availability


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