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P8861 Sigma

Pyrrolnitrin from Pseudomonas cepacia

≥98% (HPLC), solid

Synonym: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole

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Description

Specificity

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

Biochem/physiol Actions

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
UX9450000
Protocols & Articles
Peer-Reviewed Papers
15

References

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