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  • P8984 - Monoclonal Anti-Protein Tyrosine Phosphatase μ antibody produced in mouse

P8984 Sigma

Monoclonal Anti-Protein Tyrosine Phosphatase μ antibody produced in mouse

clone SBK10, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-PTPμ



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, PR-PR,
species reactivity   rat, mouse, human, bovine
application(s)   immunoprecipitation: suitable
  western blot (chemiluminescent): 1-10 μg/mL
clone   SBK10, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 200 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PTPRM(5797)
mouse ... Ptprm(19274)
rat ... Ptprm(29616)
biological source   mouse
conjugate   unconjugated



peptide corresponding to amino acid residues 42-60 of PTPμ.

General description

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. The protein phosphatases can be divided into two main groups: protein tyrosine phosphatases (PTPs) and protein serine/threonine phosphatases (PPs) which remove phosphate from proteins/peptides containing phosphotyrosine (pTyr) or phosphoserine/phosphothreonine (pSer/pThr), respectively. Several of the PTPs are known to control the function of growth factor receptors, many of which are tyrosine kinases encoded by oncogenes. PTPmu participates in homophilic binding of extracellular surface of adjacent cells. PTPmu is reported to be downregulated in glioblastoma in which it regulates cell migration and growth factor-independent survival
Monoclonal Anti-Protein Tyrosine Phosphatase mu recognizes PTPmu isoforms in all mammalian species.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.

Preparation Note

Purified from tissue culture supernatant using Protein G.


Anti-protein tyrosine phosphatase mu may be used for detection by immunoblotting at a working concentration of 1 to 10 μg/mL. The antibody is suitable for immunoprecipitation.

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Safety Information

WGK Germany  2
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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