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P8986 Sigma

Peroxiredoxin 1 human

≥85% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: NKEFA



Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ≥85% (SDS-PAGE)
form   lyophilized powder
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... PRDX1(5052)


Biochem/physiol Actions

Peroxiredoxins are a novel defined family of peroxidases of approximately 25 kDa that reduce H2O2 and alkyl hydroperoxides and use mainly the thioredoxin (Trx) system (Trx, thioredoxin reductase and NADPH) as electron donor. The peroxiredoxin family includes more than 30 proteins from organisms of all kingdoms. Peroxiredoxin I belongs to the Type I Peroxiredoxin family. This family consists of human natural killer cell enhancing factor (NKEFA), human proliferation associated gene (PAG), mouse macrophage stress induced protein (MSP23), mouse osteoblast specific factor (OSF-3), and rat heme-binding protein (HBP23). These proteins share about 95% homology.

Peroxiredoxin 1 has a role in cellular peroxide scavenging and it modulates various signaling pathways. It is over-expressed in many cancer cells. It regulates cell growth and signaling by interacting with proteins like c-jun-N-terminal kinase and c-myc.


250 μg in glass bottle


This product has been shown to catalyze NADPH oxidation in the thioredoxin-thioredoxin reductase system.

Physical form

Lyophilized powder containing HEPES buffer salts and trehalose as stabilizer.


Peroxiredoxin 1 has been used as a standard in enzyme assay for Clostridium difficile recombinant spore coat protein, cotE (with peroxiredoxin and chitinase activity).

General description

Peroxiredoxin 1, an active enzyme, has two cysteine residues which correspond to Cys 47 and Cys 170 of yeast TPx (thioredoxin peroxidase).

Price and Availability

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles
Peer-Reviewed Papers


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