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  • P9109 - Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse

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P9109 Sigma

Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse

clone AG25, purified immunoglobulin

Synonym: Anti-PTP PEST

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, PR-PR,
species reactivity   rat, bovine, human, mouse
application(s)   immunoprecipitation: suitable
  western blot: suitable
clone   AG25, monoclonal
antibody form   purified immunoglobulin
isotype   IgG1
mol wt   antigen mol wt 88 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PTPN12(5782)
mouse ... Ptpn12(19248)
rat ... Ptpn12(117255)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

full-length, recombinant PTP PEST.

General description

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. The protein phosphatases can be divided into two main groups: protein tyrosine phosphatases (PTPs) and protein serine/threonine phosphatases (PPs) which remove phosphate from proteins/peptides containing phosphotyrosine (pTyr) or phosphoserine/phosphothreonine (pSer/pThr), respectively. Several of the PTPs are known to control the function of growth factor receptors, many of which are tyrosine kinases encoded by oncogenes. PTP PEST is a cytosolic protein tyrosine phosphatase which is ubiquitously expressed in mammalian tissues. PTP PEST is subject to regulation via phosphorylation of Ser39 by both protein kinase C and protein kinase A
Monoclonal Anti-Protein Tyrosine Phosphatase PEST recognizes PTP PEST isoforms in all mammalian species (88 kDa).

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

Preparation Note

Purified from tissue culture supernatant using Protein G.

Application

Anti-Protein Tyrosine Phosphatase PEST antibody is suitable for immunoblotting and immunoprecipitation.

Price and Availability


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