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P9129 Sigma

5-Pregnen-3β-ol-20-one

≥98%

Synonym: 3β-Hydroxy-5-pregnen-20-one, Pregnenolone

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Properties

Related Categories Cell Biology, Lipid, Lipid Library Collection, Metabolic Pathways, Metabolite Libraries and Collections,
InChI Key   ORNBQBCIOKFOEO-QGVNFLHTSA-N
assay   ≥98%
solubility   ethanol: soluble10 mg/mL, clear, colorless to faintly yellow
Gene Information   human ... SERPINA6(866)
rat ... Ar(24208)

Description

Packaging

1, 5, 25, 100 g in poly bottle

Application

5-Pregnen-3β-ol-20-one is suitable for use:
• as a substrate for 3β-HSD at a concentration of 1 μg/mL to study the time-dependent effect of reduced oxygen tension on 3β-hydroxysteroid dehydrogenase (3β-HSD) activity
• as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells
• in the testicular interstitial cell culture medium at a concentration of 15mg/mL

Biochem/physiol Actions

One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.

Testosterone production in rats occurs in Leydig cells of the testis via the Δ4 pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone. Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with γ-aminobutyric acid (GABA) receptor.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P9129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TU5560700
Protocols & Articles
Peer-Reviewed Papers
15

References

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739545 Pregnenolone-20,21-13C2-16,16-d2, 98 atom % D, 98 atom % 13C, 98% (CP)
740985 Pregnenolone-20,21-13C2-16,16-d2 sulfate sodium salt, 98 atom % D, 98 atom % 13C, 98% (CP)

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