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P9523 Sigma

Plasma

from human

Synonym: Citrated plasma

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Properties

Related Categories Biochemicals and Reagents, Plasma, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives More...
biological source   from human
contains   4% trisodium citrate as anticoagulant
impurities   HIV, hepatitis B and hepatitis C, none detected
storage temp.   2-8°C

Description

Other Notes

This product is prepared from pooled human blood. It contains 4% trisodium citrate as an anticoagulant. It is tested for clotting, which indicates that the clotting factors in the product are active. However, it is not analyzed to determine whether other enzymes present are native or denatured.

Preparation Note

Whole blood collected by standard industry method using citrate based anticoagulant. Whole blood is pooled and then centrifuged. The resulting plasma is 0.45 micron filtered and lyophilized from the indicated volumes.

General description

Plasma is the liquid part of the blood and lymphatic fluid, which makes up about half of its volume. Plasma is devoid of cells and, unlike serum, has not clotted. It is prepared from whole blood that is collected with anticoagulants (9:1) and centrifuged to remove cells and cellular debris. Some of the more common proteins found in plasma are albumin and prealbumin, α1-acid glycoprotein, transferrin, lipoproteins (HDL, LDL, and VLDL), immunoglobulins, complement proteins, and coagulation proteins (thrombin, plasminogin, and fibrinogen). Citrated plasma contains citrate (4% trisodium citrate) as an anticoagulant.

Plasma contains a variety of proteins with diverse functions. The primary functions of the plasma proteins include the maintenance of colloid osmotic pressure, pH, and electrolyte balance; the transport of metal ions, fatty acids, steroids, hormones, and drugs to various organs of the body; use as a source for amino acids for tissue nourishment; hemostasis and the prevention of thrombosis; the regulation of cellular activity and function through hormone signaling; and defense against invasion through the actions of antibodies and complement components.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Development of two Multiplex Immunoassays

Depletion of Highly Abundant Protein (HAP) and Moderately Abundant Protein (MAP) from plasma or serum samples can be achieved through Sigma Seppro® Tandem IgY14/ SuperMix columns.
Jiaxin Dong, Chris Melm, Holly Chapman, Farrah Fan,Dian Er Chen, Henry Duewel
Biowire Volume 10 Article 1
Keywords: Enzyme-linked immunosorbent assay, Filtration, High performance liquid chromatography, Immobilization, Indirect ELISA, Mass spectrometry, Proteomics

Peer-Reviewed Papers
15

References

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