|Related Categories||Biochemicals and Reagents, Biomaterials, Cell Culture, Materials Science, Nucleosides, Nucleotides, Oligonucleotides,|
|assay||≥99% (less than 1% free nucleotides, TLC)|
|composition||Poly(I) • Poly(C), 10% (balance buffer salts as sodium chloride and sodium phosphate)|
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Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
Package size based on polynucleotide content
The product requires ionic strength to maintain the double-strand structure. Reconstitution at ~10 mg/mL of water yields a polynucleotide in physiological phosphate buffered solution.
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidyli
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lyophilized powder, ≥1 × 105 IRU/mg protein (IRU = International Reference Unit)
double-stranded alternating copolymer
Certificate of Analysis
Certificate of Origin
The NF-κB subunits RelB and cRel negatively regulate TLR3-mediated IFN-β production via induction of the transcriptional repressor protein YY1. Siednienko J, Maratha A, Yang S, et al. J. Biol. Chem. 286(52), 44750-63, (2011)
Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation. Bsibsi M, Nomden A, van Noort JM, Baron W. J. Neurosci. Res. 90(2), 388-98, (2011)
Activation of chemokine and inflammatory cytokine response in HCV-infected hepatocytes depends on TLR3 sensing of HCV dsRNA intermediates. Li K, Li NL, Wei D, Pfeffer SR, et al. Hepatology 55(3), 666-75, (2011)
CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice. Hansen J, Lindenstrøm T, et al. Cancer Immunol. Immunother., (2011)
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