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P9703 Sigma

Pimaricin

from Streptomyces chattanoogensis, ≥95% (HPLC)

Synonym: Natamycin

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics N-S,
Quality Level   PREMIUM
biological source   from Streptomyces chattanoogensis
InChI Key   NCXMLFZGDNKEPB-FFPOYIOWSA-N
assay   ≥95% (HPLC)
form   lyophilized powder
  powder
solubility   0.1% formic acid in methanol: soluble1 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

Biochem/physiol Actions

An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane

Packaging

25 mg in poly bottle

50, 100 mg in glass bottle

Application

Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Light sensitive.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TK3325000
Protocols & Articles
Peer-Reviewed Papers
15

References

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