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PZ0001 Sigma

Atorvastatin calcium salt trihydrate

≥98% (HPLC)

  • CAS Number 134523-03-8 (anhydrous)

  • Empirical Formula (Hill Notation) C33H34FN2O5 · 0.5 Ca · 1.5 H2O

  • Molecular Weight 604.69

  •  PubChem Substance ID 329823670

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Properties

Related Categories AN-AZ, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   SHZPNDRIDUBNMH-NIJVSVLQSA-L
assay   ≥98% (HPLC)
form   white powder
storage condition   protect from light
solubility   DMSO: ≥10 mg/mL
originator   Pfizer
storage temp.   room temp

Description

Other Notes

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5, 25 mg in glass bottle

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Application

Atorvastatin calcium salt trihydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Atorvastatin calcium salt trihydrate is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Atorvastatin is used in the treatment of hypercholesterolemia.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

General description

Atorvastatin calcium salt trihydrate is an anti-hyperlipoproteinemic and a synthetic cholesterol-reducing agent. It is a crystalline powder.

Price and Availability


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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antilipemic Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 21–24
Keywords: Anti-inflammatory agents, Cardiovascular, Chemical vapor deposition, Clinical, Diabetes, Inflammation, Oxidations, Pharmaceutical, Transcription

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Pfizer Compounds for Lipid Signaling

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Lipid Signaling

Peer-Reviewed Papers
15

References

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