|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood,|
|optical activity||[α]/D +20 to +30° in 95% ethanol|
|color||white to tan|
|solubility||DMSO: ≥12 mg/mL|
Sold for research purposes under agreement from Pfizer Inc.
Pactamycin is a potent protein synthesis inhibitor, inhibiting protein synthesis at the translocation step on the 70S ribosome. It has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial activity. Cytotoxicity limits it clinical use.
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. Dinos G, Wilson DN, Teraoka Y, et al. Mol. Cell. 13(1), 113-24, (2004)
The phosphorylation of protein S6 modulates the interaction of the 40 S ribosomal subunit with the 5'-untranslated region of a dictyostelium pre-spore-specific mRNA and controls its stability. Chiaberge S, Cassarino E, and Mangiarotti G J. Biol. Chem. 273(42), 27070-5, (1998)
The host gene for intronic U17 small nucleolar RNAs in mammals has no protein-coding potential and is a member of the 5'-terminal oligopyrimidine gene family. Pelczar P and Filipowicz W Mol. Cell. Biol. 18(8), 4509-18, (1998)
Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation. Kudo F, Kasama Y, Hirayama T, Eguchi T. J. Antibiot. 60, 492-503, (2007)
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V Cell 103, 1143-1154, (2000)
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