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PZ0182 Sigma

Pactamycin

≥95% (HPLC)

Synonym: 2-Hydroxy-6-methylbenzoic acid [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester, PNU-0015800, U-15800

  • CAS Number 23668-11-3

  • Empirical Formula (Hill Notation) C28H38N4O8

  • Molecular Weight 558.62

  •  MDL number MFCD00158126

Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood,
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D +20 to +30° in 95% ethanol
color   white to tan
solubility   DMSO: ≥12 mg/mL
storage temp.   2-8°C

Description

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

Pactamycin is a potent protein synthesis inhibitor, inhibiting protein synthesis at the translocation step on the 70S ribosome. It has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial activity. Cytotoxicity limits it clinical use.

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