Q0125 Sigma

Quercetin dihydrate

≥98% (HPLC), powder

Synonym: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate, 3,3′,4′,5,7-Pentahydroxyflavone dihydrate



Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Quercetin dihydrate is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Customers Also Viewed


≥95% (HPLC), solid

Quercetin hydrate


Safety & Documentation

Safety Information

GHS06  GHS06
Signal word 
Hazard statements 
Precautionary statements 
UN 2811 6.1 / PGIII
WGK Germany 
Protocols & Articles


Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Related Content

Carcinogen Selector - Urinary System - Kidney

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Urinary System - Kidney
Keywords: Cancer, Carcinogens, Respiratory

Carcinogen Selector - Urinary System

From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Urinary System
Keywords: Cancer, Carcinogens, Respiratory

Peer-Reviewed Papers


Set your institution to view full text papers.

Controlling Transgene Expression In Subcutaneous Implants Using A Skin Lotion Containing The Apple Metabolite Phloretin. Gitzinger, M., et al. Proc. Natl. Acad. Sci. U. S. A. 106, 10638-43, (2009)


Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Beretz, A., et al. Experientia 34, 1054, (1978)


Antioxidants and cancer, part 3: quercetin. Lamson, D.W., and Brignall, M.S. Altern. Med. Rev. 5, 196-208, (2000)


Effects of inhibitors on the plasma membrane and mitochondrial adenosine triphosphatases of Neurospora crassa. Bowman, B.J., et al. Biochim. Biophys. Acta 512, 13-28, (1978)


Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Yoshida, M., et al. Cancer Res., (1992)


Quercetin down-regulates signal transduction in human breast carcinoma cells. Singhal, R.L., et al. Biochem. Biophys. Res. Commun. 208, 425-431, (1995)


Effects Of Menadione, Hydrogen Peroxide, And Quercetin On Apoptosis And Delayed Luminescence Of Human Leukemia Jurkat T-cells. Baran, I., et al. Cell Biochem. Biophys. 58, 169-79, (2010)


Quercetin: synergistic action with carboxyamidotriazole in human breast carcinoma cells. Yeh, Y.A., et al. Life Sci. 57, 1285-1292, (1995)


Effects Of Nutritional Antioxidants On AAPH- Or AGEs-induced Oxidative Stress In Human SW872 Liposarcoma Cells. Roche, M., et al. Cell Biol. Toxicol. 25, 635-44, (2009)


bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis. Frerigmann H, Berger B, Gigolashvili T, et al. Plant Physiol. 166(1), 349-69, (2014)


Phenolic composition and antioxidant capacity of pomaces from four grape varieties (Vitis vinifera L.). de la Cerda-Carrasco A, López-Solís R, Nuñez-Kalasic H, et al. J. Sci. Food Agric. 95(7), 1521-7, (2015)


Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat. Oršoli? N, Goluža E, Diki? D, et al. Eur. J. Nutr. 53(5), 1217-27, (2014)


Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice. Matsuo T, Hattori T, Asaba A, et al. Proc. Natl. Acad. Sci. U. S. A. 112(3), E311-20, (2015)


Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis. Vandeput M, Parsajoo C, Vanheuverzwijn J, et al. J. Pharm. Biomed. Anal. 102, 267-75, (2015)


Quercetin mitigates Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats. Merzoug S, Toumi ML, Tahraoui A, et al. Naunyn Schmiedebergs Arch. Pharmacol. 387(10), 921-33, (2014)


The toxicity of NaF on BmN cells and a comparative proteomics approach to identify protein expression changes in cells under NaF-stress: impact of NaF on BmN cells. Chen L, Chen H, Yao C, et al. J. Hazard. Mater. 286, 624-31, (2015)


The potential of mycelium and culture broth of Lignosus rhinocerotis as substitutes for the naturally occurring sclerotium with regard to antioxidant capacity, cytotoxic effect, and low-molecular-weight chemical constituents. Lau BF, Abdullah N, Aminudin N, et al. PLoS ONE 9(7), e102509, (2014)


Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial. Soriano-Maldonado A, Hidalgo M, Arteaga P, et al. Eur. J. Nutr. 53(8), 1645-57, (2014)


Rice hull extracts inhibit proliferation of MCF-7 cells with G? cell cycle arrest in parallel with their antioxidant activity. Chung NJ, Choi KC, Lee SA, et al. J. Med. Food 18(3), 314-23, (2015)


Enhanced oral bioavailability of morin administered in mixed micelle formulation with PluronicF127 and Tween80 in rats. Choi YA, Yoon YH, Choi K, et al. Biol. Pharm. Bull. 38(2), 208-17, (2015)


Merck 14,8034

Beil. 18,V,5,494

Aldrich MSDS 1, 1577:B / Corp MSDS 1 (2), 3019:D / FT-IR 2 (2), 2509:C / FT-IR 1 (2), 96:B / FT-NMR 1 (2), 920:B / IR-Spectra (3), 906:F / IR-Spectra (2), 793:D / NMR-Reference 2 (2), 98:D / RegBook 1 (2), 1697:K / Sigma FT-IR 1 (2), 877:C / Structure Index 1, 270:D:1

Related Products

comparable product

Product #


Add to Cart

Q4951 Quercetin, ≥95% (HPLC), solid

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?