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Q0125 Sigma

Quercetin dihydrate

≥98% (HPLC), powder

Synonym: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one dihydrate, 3,3′,4′,5,7-Pentahydroxyflavone dihydrate

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Description

Frequently Asked Questions

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Biochem/physiol Actions

Quercetin dihydrate is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Quercetin

≥95% (HPLC), solid

Quercetin dihydrate

primary pharmaceutical reference standard

Quercetin dihydrate

European Pharmacopoeia (EP) Reference Standard

Quercetin hydrate

≥95%

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
25
Safety Statements (Europe) 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
LK8950000

Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

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Peer-Reviewed Papers

References

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Controlling Transgene Expression In Subcutaneous Implants Using A Skin Lotion Containing The Apple Metabolite Phloretin. Gitzinger, M., et al. Proc. Natl. Acad. Sci. U. S. A. 106, 10638-43, (2009)

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Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Beretz, A., et al. Experientia 34, 1054, (1978)

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Antioxidants and cancer, part 3: quercetin. Lamson, D.W., and Brignall, M.S. Altern. Med. Rev. 5, 196-208, (2000)

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Effects of inhibitors on the plasma membrane and mitochondrial adenosine triphosphatases of Neurospora crassa. Bowman, B.J., et al. Biochim. Biophys. Acta 512, 13-28, (1978)

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Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Yoshida, M., et al. Cancer Res., (1992)

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Quercetin down-regulates signal transduction in human breast carcinoma cells. Singhal, R.L., et al. Biochem. Biophys. Res. Commun. 208, 425-431, (1995)

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Effects Of Menadione, Hydrogen Peroxide, And Quercetin On Apoptosis And Delayed Luminescence Of Human Leukemia Jurkat T-cells. Baran, I., et al. Cell Biochem. Biophys. 58, 169-79, (2010)

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Quercetin: synergistic action with carboxyamidotriazole in human breast carcinoma cells. Yeh, Y.A., et al. Life Sci. 57, 1285-1292, (1995)

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Effects Of Nutritional Antioxidants On AAPH- Or AGEs-induced Oxidative Stress In Human SW872 Liposarcoma Cells. Roche, M., et al. Cell Biol. Toxicol. 25, 635-44, (2009)

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Merck 14,8034

Beil. 18,V,5,494

Aldrich MSDS 1, 1577:B / Corp MSDS 1 (2), 3019:D / FT-IR 2 (2), 2509:C / FT-IR 1 (2), 96:B / FT-NMR 1 (2), 920:B / IR-Spectra (3), 906:F / IR-Spectra (2), 793:D / NMR-Reference 2 (2), 98:D / RegBook 1 (2), 1697:K / Sigma FT-IR 1 (2), 877:C / Structure Index 1, 270:D:1

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Q4951 Quercetin, ≥95% (HPLC), solid

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