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Q0380 Sigma

Quinone Oxidoreductase 2 (NQO2) human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein

Synonym: NQO2 human, NRH nitroreductase human, NRH quinone reductase human

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Properties

Related Categories Cancer Research, Cancer Research Enzymes, Cell Biology, Multidrug Resistance, Phase II Enzymes More...
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   lyophilized powder (one vial contains one mg protein)
storage temp.   −20°C
Gene Information   human ... NQO2(4835)

Description

Biochem/physiol Actions

Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.

Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.

Unit Definition

One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.

Physical form

contains 10% PBS buffer salts

Application

Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat’s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.

The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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