Rapamycin from Streptomyces hygroscopicus

Papers

Rapamycin: in vitro profile of a new immunosuppressive macrolide. Sehgal, S.N. and Bansback, C.C. Ann. N. Y. Acad. Sci. 685, 58-67, (1993)

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Mita, MM, et al. Cancer Biol. Ther. 2, S169-S177, (2003)

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Upstream of the mammalian target of rapamycin; do all roads pass through mTOR? Corradetti MN, and Guan KL. Oncogene 25, 6347-6360, (2006)

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Targeting the mTOR signaling network in cancer Chiang GG, and Abraham RT. Trends Mol. Med. 13, 433-442, (2007)

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Targeting mTOR with rapamycin; One dose does not fit all Foster DA, Toschi A. Cell Cycle 2, 8, (2009)

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Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes. Sasai, N., et al. Muscle Nerve 41, 100-6, (2010)

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Monitoring The Autophagy Pathway In Cancer. Dorsey, F.C., et al. Meth. Enzymol. 453, 251-71, (2009)

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Degradation Of Regulator Of Calcineurin 1 (RCAN1) Is Mediated By Both Chaperone-mediated Autophagy And Ubiquitin Proteasome Pathways. Liu, H., et al. FASEB J. 23, 3383-92, (2009)

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TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, And Survival Under DNA-damaging Conditions. Schonbrun, M., et al. Mol. Cell. Biol. 29, 4584-94, (2009)

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Biosynthesis And Expression Of VE-cadherin Is Regulated By The PI3K/mTOR Signaling Pathway. Bieri, M., et al. Mol. Immunol. 46, 866-72, (2009)

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From The Cover: Bifurcation Of Insulin Signaling Pathway In Rat Liver: MTORC1 Required For Stimulation Of Lipogenesis, But Not Inhibition Of Gluconeogenesis Li, S., et al. Proc. Natl. Acad. Sci. U. S. A. 107, 3441-3446, (2010)

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The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Mita, MM, et al. Cancer Biol. Ther. 2, S169-S177, (2003)

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Integration of growth factor and nutrient signaling: implications for cancer biology. Shamji, A.F., et al. Mol. Cell. 12, 271-280, (2003)

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mTOR as a positive regulator of tumor cell responses to hypoxia. Abraham, R.T. Curr. Top. Microbiol. Immunol. 279, 299-319, (2004)

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Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford Progeria Syndrome cells. Cao, K. et al. Sci. Transl. Med. 3, (2011)

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Merck 14,8114