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R0400 Sigma

RANK/Fc Chimera human

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, RANK, Osteoprotegerin and TRAIL,
recombinant   expressed in NSO cells
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... TNFRSF11A(8792)

Description

Analysis Note

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

Biochem/physiol Actions

The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE (TNF-related activation-induced cytokines)-induced biological activity.

Other Notes

The DNA sequence encoding the extracellular domain of human RANK is fused to the signal peptide of CD33 at the amino-terminus and also fused the carboxy-terminal 6X histidine-tagged Fc region of human IgG1, via a polypeptide linker.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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