Reserpine

Papers

Moxonidine: a review of safety and tolerability after seven years of clinical experience. Schachter, M. J. Hypertens. 17, S37-S39, (1999)

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Experimental models of Parkinson's disease: insights from many models. Tolwani, R,J., et al. Lab. Anim. Sci. 49, 363-371, (1999)

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In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae. Arnold Louie, David L. Brown, et al. Antimicrob. Agents Chemother. 51, 3988-4000, (2007)

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Indole alkaloids and other constituents of Rauwolfia serpentina. Atsuko Itoh et al J. Nat. Prod. 68, 848-52, (2005)

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N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. Serge Michalet et al Bioorg. Med. Chem. Lett. 17, 1755-8, (2007)

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Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus. Jérémie Fournier Dit Chabert et al Bioorg. Med. Chem. 15, 4482-97, (2007)

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New functional assay of P-glycoprotein activity using Hoechst 33342. Henrik Müller et al Bioorg. Med. Chem. 15, 7470-9, (2007)

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The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. Eileen C J Smith et al Antimicrob. Agents Chemother. 51, 4480-3, (2007)

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Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Céline Vidaillac et al Antimicrob. Agents Chemother. 51, 831-8, (2007)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Johannes Kornhuber et al J. Med. Chem. 51, 219-37, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump. Stefano Sabatini et al J. Med. Chem. 51, 4321-30, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. D Shyamali Wimalasena et al J. Med. Chem. 51, 760-8, (2008)

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Citral derived amides as potent bacterial NorA efflux pump inhibitors. Niranjan Thota et al Bioorg. Med. Chem. 16, 6535-43, (2008)

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Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Anne Pick et al Bioorg. Med. Chem. 16, 8224-36, (2008)

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Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. P. L. Sangwan, et al., Bioorg. Med. Chem. 16, 9847-9857, (2008)

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Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps. Nadezhda German et al Eur. J. Med. Chem. 43, 2453-63, (2008)

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The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB. Mark I Garvey et al Antimicrob. Agents Chemother. 52, 1677-85, (2008)

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Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. Lilia Chérigo et al J. Nat. Prod. 71, 1037-45, (2008)

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Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Shuang Chang et al Nat. Chem. Biol. 4, 256-63, (2008)

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Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Santiago Ramón-García et al Antimicrob. Agents Chemother. 53, 3675-82, (2009)

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Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor. James J Vecchione et al Antimicrob. Agents Chemother. 53, 4673-7, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps. Marco Pieroni et al J. Med. Chem. 53, 4466-80, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus. Niranjan Thota et al Eur. J. Med. Chem. 45, 3607-16, (2010)

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LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Jody L Floyd et al Antimicrob. Agents Chemother. 54, 5406-12, (2010)

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Discovery of novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus. Jean Pierre Brincat et al J. Med. Chem. 54, 354-65, (2011)

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Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. Stefano Sabatini et al J. Med. Chem. 54, 5722-36, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Capture hydrolysis signals in the microsomal stability assay: Molecular mechanisms of the alkyl ester drug and prodrug metabolism. Hao Sun et al Bioorg. Med. Chem. Lett. 22, 989-95, (2012)

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Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells. Gabriela Figueroa-González et al J. Nat. Prod. 75, 93-7, (2012)

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Merck 14,8145

Beil. 25,IV,1319