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  • R0900 - Anti-RANK (TRANCE-R) antibody produced in goat

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R0900 Sigma

Anti-RANK (TRANCE-R) antibody produced in goat

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors,
species reactivity   mouse
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Tnfrsf11a(21934)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant mouse RANK extracellular domain expressed in Sf 21 insect cells.

General description

RANK also refers as TRANCE receptor (TRANCE R) or osteoclast differentiation factor (ODFR) is a receptor activator of NF-κB that belongs to the tumor necrosis factor receptor (TNFR) family. It is extensively expressed in skeletal muscle, small intestine, liver, colon, thymus and adrenal gland. It facilitates several biological functions like activating NF-κB and c-jun N-terminal kinase, enhancing T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. RANK (receptor activator of NF-κB) along with RANK ligand (RANKL) assists in regulation of interactions between T cells and dendritic cells. Anti-RANK (TRANCE-R) antibody can be used in indirect ELISA. Goat anti-RANK (TRANCE-R) antibody reacts specifically with recombinant mouse RANK. The product has also shown 20% cross-reactivity with recombinant human RANK.

Physical form

Lyophilized from a 0.2 μm-filtered solution in phosphate buffered saline with 5% trehalose.

Specificity

Binding of antibody to cell surface RANK can trigger signal transduction and induce RANK-mediated bioactivity. By ELISA, the antibody shows 20% cross-reactivity with recombinant human RANK.

Application

Anti-RANK (TRANCE-R) antibody can be used in western blotting (0.1-0.2 mug/mL).

Price and Availability


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