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R128 Sigma

Monoclonal Anti-Ryanodine Receptor antibody produced in mouse

clone C3-33, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   amphibian, chicken, canine, rat, fish, rabbit, human, guinea pig, mouse
application(s)   immunohistochemistry (frozen sections): 1 μg/mL using 4% paraformaldehyde-fixed, frozen mouse brain tissue
  immunoprecipitation: suitable
  western blot (chemiluminescent): 1 μg/mL
clone   C3-33, monoclonal
concentration   ~1 mg/mL
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt ~565 kDa (non-mammalian vertebrates, a doublet at 565 kDa represents the α and β isoforms)
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Ryr1(114207), Ryr2(84025)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

dog cardiac ryanodine receptors (RyR)

Physical form

ascites fluid containing PBS and 0.05% sodium azide.

Specificity

The antibody reacts strongly with RyR-2 (expressed predominantly in the heart muscle, but also found in stomach, endothelial cells and diffuse areas of the brain; also known as the β isoform), and weakly with RyR-1 (expressed predominantly in skeletal muscle and areas of the brain; also known as the α isoform). It reacts with ryanodine receptor in cardiac muscle of canine, rat, finch and pigeon; in visceral smooth muscle of toad; and in rat brain. It reacts with skeletal muscle of fish and the β isoform of frog, but only weakly with skeletal muscle in rabbit and the α isoform of frog. In immunohistochemistry, the antibody stains are consistent with the endoplasmic reticulum localization of the receptor in the hippocampus.

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