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R1408 Sigma

RU7

≥98% (HPLC)

Synonym: 5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

  • CAS Number 355400-87-2

  • Empirical Formula (Hill Notation) C14H11Br2NO5S2

  • Molecular Weight 497.18

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Gene Regulation and Expression
assay   ≥98% (HPLC)
form   powder
color   yellow
solubility   DMSO: ≥20 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.

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