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R2146 Sigma

Radicicol from Diheterospora chlamydosporia Green Alternative

solid

Synonym: Monorden, [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antifungal,
InChI Key   WYZWZEOGROVVHK-GTMNPGAYSA-N
form   solid
greener alternative product score   old score: 15
new score: 9
Find out more about DOZN™ Scoring.
greener alternative product characteristics   Waste Prevention
Atom Economy
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.
color   yellow
solubility   ethanol: soluble10 mg/mL
Mode of action   enzyme | inhibits
greener alternative category   Re-engineered
storage temp.   −20°C
Gene Information   human ... HSP90AA1(3320), SRC(6714)
rat ... Src(83805)

Description

Biochem/physiol Actions

Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.

Caution

Photosensitive

Packaging

1, 5 mg in glass bottle

Price and Availability


DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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