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R2625 Sigma

Retinoic acid

≥98% (HPLC), powder

Synonym: ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5 g in ampule

50, 100, 500 mg in ampule

Application

• Retinoic acid (RA) has been used for the differentiation of embryonic stem cells into motor neurons.
• It has been used for the differentiation of Xenopus ectoderm into pancreas.
• It has also been used to study epigenetic regulation by RARα (retinoic acid receptor α).
• It has been used to study RA signaling of prospermatogonia transition into spermatogonia.

Biochem/physiol Actions

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R2625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
VH6475000

Frequently Asked Questions

What are the I.U. for Product R2625, Retinoic acid?
This product is not characterized by the activity in I.U. The purity specification, however, is not less than 98% by HPLC. Click on the following link to view R2625 Specifications: http://www.sigmaaldrich.com/catalog/search/SpecificationSheetPage/SIGMA/R2625
What is Product R2625, Retinoic acid soluble in?
Retinoic Acid is soluble in DMSO at about 40 mg/ml. This information can be found on R2625 Product Information sheet by clicking on the following link:http://www.sigmaaldrich.com/sigma/product%20information%20sheet/r2625pis.pdf
How should I store the solutions of Product R2625, Retinoic acid?
Retinoic acid is sensitive to air and light. Solutions should be stored under argon gas, preferably as aliquots at -70 deg. C. This information can be found on R2625 Product Information sheet by clicking on the following link:http://www.sigmaaldrich.com/sigma/product%20information%20sheet/r2625pis.pdf
What is the shelf life of Product R2625, Retinoic acid?
R2625 has a shelf-life of two years. Shelf-life dates are found on Specification sheet on our website. Click on the following link to view R2625 Specifications:http://www.sigmaaldrich.com/catalog/search/SpecificationSheetPage/SIGMA/R2625
Why is Product R2625, Retinoic acid not shipped on dry ice?
Dry ice is not necessary for shipment, since Product No. R2625 is stable to ship at ambient temperature for up to two weeks. Once received, it should be stored at -20°C.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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