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  • R3151 - Monoclonal Anti-Rhodopsin Kinase 1A antibody produced in mouse

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R3151 Sigma

Monoclonal Anti-Rhodopsin Kinase 1A antibody produced in mouse

clone G8, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-GRK1a

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, G Protein-coupled Receptor Kinase (GRK),
species reactivity   rat, bovine, chicken, human, mouse
application(s)   immunoprecipitation: suitable
  indirect immunofluorescence: suitable
  western blot: suitable
clone   G8, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... GRK1(6011)
mouse ... Grk1(24013)
rat ... Grk1(81760)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

derived from human GRK1

General description

GRK1 (rhodopsin kinase) is an enzyme that belongs to serine/threonine protein kinase family and expresses mainly in rod and cone photoreceptors. It has a crucial role in phosphorylation of photoactivated rhodopsin and hence starting steps in its deactivation. Monoclonal anti-rhodopsin kinase 1a antibody can be used in immunoprecipitation. Mouse anti-rhodopsin kinase 1a antibody reacts specifically with an epitope present in the C-terminal region of mouse, bovine, rat, chicken and human GRK1a. The product has shown no cross-reactivity with other G protein coupled kinases together with GRK1b.

Antigen Background

Rhodopsin Kinase 1A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation.

Physical form

Supplied in phosphate buffered saline containing 0.05% sodium azide.

Application

Monoclonal anti-rhodopsin kinase 1a antibody can be used in indirect immunofluorescence and western blotting.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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