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Role of Catechol Quinone Species in Cellular Toxicity

  •  ISBN-10 1-929675-00-3

  •  ISBN-13 978-1-929675-00-5

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publication info   C.R. Creveling, ed., F.P. Graham Publishing, 2000, 266 pp., hard cover

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This book provides in-depth description and analysis of the potential of catecholamine-quinones to destroy nerves in which they are synthesized, mechanisms by which this occurs, sites at which intervention is possible, and role of astroglia. Insight is gleaned from mechanisms of action of several neurotoxins, while analysis of mechanisms of chemically-related tetrahydroisoquinolines provides recognition of the neurotoxic potential of endogenously formed orthoquinones from catecholamines. This book is of value to those investigating catecholamine mechanisms of action, neurotoxins, Parkinson′s Disease and other neurodegenerative disorders, carcinogenicity, particularly melanoma, and other cancers like leukemia.

Table of Contents

1 The Role of Catecholamine ortho-Quinones in the Brain in Health and Disease
2 One and Two-Electron Reduction of Catecholamine ortho-Quinones
3 Role of Quinones in Catechol Neurotoxicity
4 Pro- and Antioxidant Effects of Catechols
5 Neuroprotective Properties of Manganese: Its Implications in Pathogenesis and Treatment of Parkinson’s Disease
6 Dopamine-induced Toxicity and Quinone Modification of Protein: Implications for Parkinson’s Disease
7 Dopamine and Oxidative Consequences: The Methamphetamine Model
8 Oxidative Deamination of Monoamine and Biogenic Aldehydes in Neurodegeneration
9 Catechol Bioactivation by Peroxidase-Positive Astroglia in Aging Neural Tissues
10 Tetrahydroisoquinolines (TIQ) and Neurodegeneration
11 Mechanisms of Control of the Cytotoxicity of Orthoquinone Intermediates of Melanogenesis
12 The Key Role of Endogenous Catechol Estrogen-3,4-Quinones in Tumor Initiation

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