9-cis-Retinoic acid ≥98% (HPLC)

Properties

Related Categories	Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, Isoprenoids, Lipids, Nutrition Research, PPAR and RXR Regulators, Prenols, R, Vitamin A, Vitamins More...
assay	≥98% (HPLC)
storage temp.	−20°C
Gene Information	human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)

Description

Packaging

Sealed ampule

Biochem/physiol Actions

Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R4643.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Related Papers

Cytosporone B is an agonist for nuclear orphan receptor Nur77. Zhan, Y., et al Nat. Chem. Biol. 4, 548-56, (2008)

Documents

Certificate of Analysis

Certificate of Origin

R4643 - Product Information Sheet (23 KB)

Safety Information

Symbol	GHS07, GHS08
Signal word	Danger
Hazard statements	H315-H319-H335-H360
Precautionary statements	P201-P261-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T
Risk Statements (Europe)	61-36/37/38
Safety Statements (Europe)	53-26-36/37/39-45
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Teratogens, Transcription, Ubiquitinations, Vitamins