|Related Categories||Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology,|
|Gene Information||human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)|
Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R4643.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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|Precautionary statements||P201-P261-P305 + P351 + P338-P308 + P313|
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||61-36/37/38|
|Safety Statements (Europe)||53-26-36/37/39-45|
The receptors for several classes of non-steroidal compounds, including retinoids, thyroid hormones and vitamin D, also act as ligand-dependent transcription factors. In addition, a large number of r...
Keywords: Absorption, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Clinical, Detoxification, Diabetes, Diseases, Gene expression, Hormones, Ligands, Lipid Metabolism, Metabolism, Metabolites, Obesity, Transcription, Transduction, Vitamins
All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Teratogens, Transcription, Ubiquitinations, Vitamins
Combined oral alitretinoin and narrowband UVB treatment of cutaneous T cell lymphoma: favourable response after multiple ineffective systemic therapies. Motschenbacher S, Buder K, Goebeler M, et al. Eur. J. Dermatol. 22(6), 803-4, (2012)
Human monocyte responses to lipopolysaccharide and 9-cis retinoic acid after laparoscopic surgery for colon cancer. Kolseth IB, Førland DT, Risøe PK, et al. Scand. J. Clin. Lab. Invest. 72(8), 593-601, (2012)
9-Cis-retinoic acid induces growth inhibition in retinoid-sensitive breast cancer and sea urchin embryonic cells via retinoid X receptor α and replication factor C3. Maeng S, Kim GJ, Choi EJ, et al. Mol. Endocrinol. 26(11), 1821-35, (2012)
Extended treatment with oral alitretinoin for patients with chronic hand eczema not fully responding to initial treatment. Lynde C, Cambazard F, Ruzicka T, et al. Clin. Exp. Dermatol. 37(7), 712-7, (2012)
Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis. Ruebner M, Langbein M, Strissel PL, et al. J. Cell. Biochem. 113(7), 2383-96, (2012)
Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets. Dal Col J, Mastorci K, Faè DA, et al. Cancer Res. 72(7), 1825-35, (2012)
Efficacy and tolerability of alitretinoin for chronic hand eczema under daily practice conditions: results of the TOCCATA open study comprising 680 patients. Diepgen TL, Pfarr E, and Zimmermann T Acta Derm. Venereol. 92(3), 251-5, (2012)
Oral alitretinoin in congenital ichthyosis: a pilot study shows variable effects and a risk of central hypothyroidism. Gånemo A, Sommerlund M, and Vahlquist A Acta Derm. Venereol. 92(3), 256-7, (2012)
9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Choi I, Lee S, Kyoung Chung H, et al. Circulation 125(7), 872-82, (2012)
The influence of 9-cis-retinoic acid on nuclear and cytoplasmic maturation and gene expression in canine oocytes during in vitro maturation. Liang S, Kang J, Jin H, et al. Theriogenology 77(6), 1198-205, (2012)
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