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R5010 Sigma

Resveratrol

≥99% (HPLC)

Synonym: 3,4′,5-Trihydroxy-trans-stilbene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Selective inhibitor of COX−1.

Biochem/physiol Actions

Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-γ-activated receptor coactivator-1α (PGC-1α) and FOXO activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation.

Packaging

100, 500 mg in poly bottle

Preparation Note

Soluble in ethanol, DMSO, and acetone. Only very slightly soluble in water (3 mg/100 mL).

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CZ8987000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I dissolve Resveratrol, Product R5010?
We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.
How do I store Resveratrol, Product R5010, once in solution?
A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light. Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL. Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995).  
In what applications do researchers use Resveratrol, Product R5010?
There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.
Can Resveratrol, Product R5010, be used as a treatment for human patients?
No. Unfortunately, none of our catalog items are suitable for pharmaceutical applications.  To inquire further on our ability to provide USP material please email our SAFC Pharma group at SAFCglobal@sial.com.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Balancing Histone/Protein Acetylation: Gene Regulation and Cancer Therapy

A highly sophisticated mechanism organizes the 2-meter long human genome within a 6-μm wide nucleus. Up to 10,000-fold of compaction of the chromatin is achieved during mitosis, allowing faithful seg...
Min-Hao Kuo
LSI Volume 7 Article 1
Keywords: Acetylations, Anaerobic, Apoptosis, Biochemistry, Cancer, Catalysis, Cell division, Cell proliferation, Chromatin immunoprecipitation, Clinical, DNA replication, Degradations, Environmental, Enzymology, Gene expression, Genetic, Genetics, Hormones, Immunoprecipitation, Indicators, Mass spectrometry, Metal organic frameworks, Methylations, Microarray Analysis, Molecular biology, Phase transitions, Phosphorylations, Recombination, Substitutions, Transcription

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

GC Analysis of Resveratrol in Red Wine (Spiked) on SLB®-5ms after SPME using a 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Resveratrol in Red Wine (Spiked) on SLB®-5ms after SPME using a 85 μm Polyacrylate Fiber
Keywords: Chromatography, Derivatizations, Gas chromatography, Mass spectrometry, Purification, Solid phase microextractions

GC Analysis of Resveratrol in Red Wine on SLB®-5ms after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Resveratrol in Red Wine on SLB®-5ms after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Derivatizations, Gas chromatography, Purification, Solid phase microextractions

Histone Modification and Chromatin Remodeling

Gene expression is governed by complex mechanisms including transcription factor binding to DNA and coordinated changes in chromatin structure. The primary protein components of chromatin are the his...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 10–16
Keywords: Acetylations, Amplification, Cancer, Cell culture, Chromatin immunoprecipitation, Cloning, DNA purification, Diseases, Gene expression, Immunoprecipitation, Indicators, Methylations, Microarray Analysis, PAGE, Polymerase chain reaction, Polymerase chain reaction - quantitative, Polymorphisms, Purification, Sequencing, Transcription, Whole genome amplification

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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