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R5143 Sigma

Rutin hydrate

≥94% (HPLC), powder

Synonym: Quercetin-3-rutinoside hydrate, Vitamin P hydrate

  • CAS Number 207671-50-9

  • Empirical Formula (Hill Notation) C27H30O16 · xH2O

  • Molecular Weight 610.52 (anhydrous basis)

  •  Beilstein Registry Number 75455

  •  EC Number 205-814-1

  •  MDL number MFCD01319140

  •  PubChem Substance ID 24899379

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Description

Biochem/physiol Actions

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

Protocols & Applications

Ginkgo (Ginkgo biloba) Plant Profile: bioactives, mechanism of action, references

Price and Availability


Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 354 nm)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 354 nm)
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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