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  • R5782 - Anti-RUVBL1 (6-20) antibody produced in rabbit

R5782 Sigma

Anti-RUVBL1 (6-20) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-ECP54, Anti-INO80H, Anti-NMP238, Anti-PONTIN, Anti-Pontin52, Anti-RVB1, Anti-RuvB-like 1 isoform 1, Anti-TIH1, Anti-TIP49, Anti-TIP49A



Related Categories Alphabetical Index, Antibodies, Antibodies to Transcription Factors, Epigenetics, Primary Antibodies,
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~50 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... RUVBL1(8607)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 6-20 of human RUVBL1

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

RUVBL1 (RuvB-like AAA ATPase 1) is involved in various cellular processes including transcriptional regulation, DNA replication, DNA damage repair, chromatin remodeling and apoptosis. In the chromatin-remodeling process, it conjugates with other proteins to form the human histone acetylase/chromatin-remodeling complex TIP60, which plays an essential role in transcription and DNA repair. The chromatin-remodeling complex regulates chromatin structure as well as it maintains DNA-based export in the cell. It also functions as a component of the human RNA polymerase II holoenzyme complex, which indicates its role in transcriptional processes. RUVBL1 is also associated with two oncogenic pathways, c-Myc and another, β-catenin pathways. In addition, it also performs in small nucleolar ribonucleoprotein particle assembly, nucleolar localization, and trafficking.

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