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R7385 Sigma

Phosphoramidon disodium salt

≥97% (TLC)

Synonym: N-(α-Rhamno­pyranosyl­oxy­hydroxy­phosphinyl)-Leu-Trp disodium salt, N-(α-Rhamno­pyranosyl­phos­phono)-L-leucyl-L-tryptophan disodium salt

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Description

Application

Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase. Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.

Biochem/physiol Actions

Potent inhibitor of thermolysin and other metallo-endopeptidases. Strongly inhibits mammalian enkephalinase. Does not inhibit trypsin, papain, chymotrypsin or pepsin. Weakly inhibits collagenase. Effective concentration 1-10 μM.

Packaging

0.5, 1, 5 mg in glass bottle

10, 25 mg in poly bottle

Substrates

Solubility testing at 10 mg/ml in water yields a clear, colorless to light yellow-green solution. The product is also soluble in methanol and DMSO; less soluble in ethanol and ethyl acetate; insoluble in benzene, hexane, and chloroform.
Solutions can be stored in aliquots at -20 °C with an expected shelf life of at least one month.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


Ultrafree Centrifugal Filter Units
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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