• USA Home
  • R7385 - Phosphoramidon disodium salt

EMAIL THIS PAGE TO A FRIEND
R7385 Sigma

Phosphoramidon disodium salt

≥97% (HPLC)

Synonym: N-(α-Rhamno­pyranosyl­oxy­hydroxy­phosphinyl)-Leu-Trp disodium salt, N-(α-Rhamno­pyranosyl­phos­phono)-L-leucyl-L-tryptophan disodium salt

Purchase

Description

Application

Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase. Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.

Biochem/physiol Actions

Potent inhibitor of thermolysin and other metallo-endopeptidases. Strongly inhibits mammalian enkephalinase. Does not inhibit trypsin, papain, chymotrypsin or pepsin. Weakly inhibits collagenase. Effective concentration 1-10 μM.

Packaging

0.5, 1, 5 mg in glass bottle

10, 25 mg in poly bottle

Substrates

Sigma tests the solubility of the Phosphoramidon sodium at 50 mg per ml in water.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


Ultrafree Centrifugal Filter Units

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?