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R7632 Sigma

Retinol

synthetic, ≥95% (HPLC), crystalline

Synonym: Axerophthol, Vitamin A alcohol, Vitamin A, Vitamin A1, all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol

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Properties

Related Categories Antitumor Agents, Biochemicals and Reagents, Cancer Research, Carotenoid, Cell Biology,
biological source   synthetic
InChI Key   FPIPGXGPPPQFEQ-OVSJKPMPSA-N
assay   ≥95% (HPLC)
form   crystalline
color   yellow
mp   61-63 °C(lit.)
absorption   ε/326 nm, isopropanol 2700 u/mg
shipped in   dry ice
storage temp.   −20°C

Description

Packaging

1 g in ampule

100, 250, 500 mg in ampule

Bottomless glass bottle. Contents are inside inserted fused cone.

Light protecting glass vial.

Application

• Retinol has been used for the synthesis of all-trans-retinoic acid in HepG2 cells.
• It has been used to study the effect of retinol on the growth of murine normal colonic cells cultured as organoids.
• It has been used as a standard for determination of vitamin A in cells.

General description

Retinol or vitamin A alcohol is the main circulating form of vitamin A. It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid. All-trans and 9-cis-retinoic acid are the ligands for nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). These receptors are transcriptional regulators of various genes.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R7632.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
VH6750000
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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