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R8779 Sigma

Monoclonal Anti-Rab7 antibody produced in mouse

~2 mg/mL, clone Rab7-117, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-Ras-associated protein

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytoplasm,
species reactivity   bovine, rat, mouse, human, chicken, monkey
application(s)   immunocytochemistry: suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  microarray: suitable
  western blot: 0.5-1 μg/mL using HeLa total cell extract
clone   Rab7-117, monoclonal
concentration   ~2 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2b
mol wt   mol wt ~24 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... RAB7A(7879)
mouse ... Rab7(19349)
rat ... Rab7a(29448)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 163-177 of human Rab7.

General description

Rab7 is a member of the Rab family of small guanosine triphosphatases (GTPases). This family belongs to the Ras superfamily of small GTPases. Rab GTPases are central regulators of membrane trafficking between different subcellular compartments in eukaryotic cells. Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. Rab7 is also involved in the maturation of late autophagic vacuoles. Among Rab7 effectors are RILP (Rab-interacting lysosome protein) that controls late endosomal and lysosomal transport by mediating the recruitment of dynein/dynactin motors, Rabring7 (Rab7-interacting ring finger protein), and the hVPS34/p150 complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

Monoclonal Anti-Rab7 recognizes human, monkey, bovine, rat, mouse, and chicken Rab7.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)

Monoclonal Anti-Rab7 antibody is suitable for the detection of Rab7using ELISA, immunoblotting (~24 kDa), immunoprecipitation, and immunocytochemistry applications.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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R4779 Anti-Rab7 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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