|Related Categories||Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Pfizer Compounds|
|biological source||from Streptomyces hygroscopicus|
|sterility||0.2 μm filtered|
|concentration||2.5 mg/mL in DMSO (2.74 mM)|
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Certificate of Analysis
|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
|RIDADR||NA 1993 / PGIII|
|Flash Point(F)||188.6 °F|
|Flash Point(C)||87 °C|
The membranes of all metazoan cells contain a substantial amount of phosphatidylinositol (PtdIns) and at least seven phosphorylated PtdIns derivatives (PPIn) at 30- to 1000-fold lower concentrations....
Keywords: Cancer, Catalysis, Gene expression, Genetic, Growth factors, Phosphorylations
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. Masliah E, Rockenstein E, Mante M, et al. PLoS ONE 6(4), e19338, (2011)
Phosphorylation of eukaryotic translation initiation factor 2α coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Jenny B. DuRose et al Mol. Cell. Biol. 29, 4295-307, (2009)
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