|Related Categories||Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Pfizer Compounds|
|biological source||from Streptomyces hygroscopicus|
|sterility||0.2 μm filtered|
|concentration||2.5 mg/mL in DMSO (2.74 mM)|
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Certificate of Analysis
|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
|RIDADR||UN 1993 / PGIII|
|Flash Point(F)||188.6 °F|
|Flash Point(C)||87 °C|
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. Masliah E, Rockenstein E, Mante M, et al. PLoS ONE 6(4), e19338, (2011)
Phosphorylation of eukaryotic translation initiation factor 2α coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Jenny B. DuRose et al Mol. Cell. Biol. 29, 4295-307, (2009)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?