R8781 Sigma

Rapamycin

Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

Synonym: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution

Properties

Related Categories Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Pfizer Compounds
Quality Level   PREMIUM
biological source   from Streptomyces hygroscopicus
sterility   0.2 μm filtered
assay   ≥95% (HPLC)
concentration   2.5 mg/mL in DMSO (2.74 mM)
storage temp.   −20°C

Description

Biochem/physiol Actions

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

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