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R9400 Sigma

Monoclonal Anti-RANTES antibody produced in rat

clone 53405.111, purified immunoglobulin, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells, Antibodies for Stem Cell Biology,
species reactivity   mouse
application(s)   immunocytochemistry: 8-25 μg/mL using mouse splenocytes
  neutralization: suitable
clone   53405.111, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   mouse ... Ccl5(20304)
biological source   rat
purified by   using protein G
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived, recombinant mouse RANTES.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.

Biochem/physiol Actions

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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Peer-Reviewed Papers
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