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R9894 Sigma

Ras human

Wild type, recombinant, expressed in E. coli, buffered aqueous glycerol solution

Synonym: H-Ras, rH-RAS, WT

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Properties

Related Categories Cancer Research, Cell Biology, Cell Signaling and Neuroscience, G Protein Function, G Protein Function Enzymes,
recombinant   expressed in E. coli
assay   ≥80% (SDS-PAGE)
form   buffered aqueous glycerol solution
mol wt   mol wt 21 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... RASGEF1B(153020)

Description

Packaging

Package size based on protein content

Substrates

A guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to MAP kinase cascade. Ras is a substrate for farnesyltransferase (FTase); when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for new anti-cancer drug development, since abnormally active Ras is present in more than 50% of human cancers.

Physical form

Solution in 50% glycerol containing 50 mM Tris (pH 8.0), 5 mM MgCl2, 45 mM NaCl, 1 mM DTT

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Biofiles, Cancer, Citric Acid Cycle, Degradations, Environmental, Events, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations, Support

Peer-Reviewed Papers
15

References

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