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S0149 Sigma

Streptolysin O from Streptococcus pyogenes

γ-irradiated

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Description

Application

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Preparation Note

Prepared from S 5265

Unit Definition

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Biochem/physiol Actions

Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
Protocols & Articles

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Peer-Reviewed Papers
15

References

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